Wednesday, July 31, 2019
Compare and Contrast the Classical and Positivist School
Compare and contrast the ideas of Classical criminologist (e. g. Beccaria and Bentham) with those of the early Positivist (e. g. Lombroso, Ferri Garofolo). IntroductionDuring the mid to late seventeenth century explanations of crime and punishment were embraced by many philosophers Thomas Hobbs (1588-1679), John Locke (1632-1704), and Jean-Jacques Rousseau (1712-1778) and such theorist as Beccaria (1738), an Italian who was highly recognised by his great success through his essay ââ¬â¢Dei delitti e delle peneââ¬â¢ (On Crimes and Punishment) publicised in translations of 22 languages, effectively leaving huge impressions on the legal thoughts on members of the European and US society (Hopkins Burke 2009), developing the theory of ââ¬ËClassical criminologyââ¬â¢ and Lombroso (1835) an Italian psychiatrist and a physician who brought forth the theory of the ââ¬ËPositivistââ¬â¢s criminologyââ¬â¢. This essay will present the two contrasting theories within criminology, these are ââ¬Ëthe Classicalââ¬â¢ and ââ¬Ëthe Positivistââ¬â¢ theory of criminology, presenting a brief introduction to each school of thought with the theories and their theorist, comparisons will drawn presenting contrasts to each theoryââ¬â¢s principle, with their methodological, scientific and philosophical approaches to crime, with the same aim to reduce and control crime. Hale,C. ,et al (2005 p. 62).The school of thought ââ¬ËClassical criminologyââ¬â¢ developed during the times of enlightenment through the ideas of a theorist named Cesare Beccaria (1738-94), who studied crimes, criminal behaviour and punishments, with beliefs that those who commit crime hold responsibility for themselves and are uninfluenced by external factors building the foundations for other successful proponents and advocates such as Cesare Lombroso (1836-1909), an Italian psychiatrist aspirant who presented theoretical explanations to crime and criminality though scientific methodolo gy adapting the contrasting theory of the positivist Contrastingly, the positivist school believed that the decisions people make when committing a crime are principally affected by ââ¬Ëmeans' out of their control. These ââ¬Ëmeans' that affect an individual's condition to make rational decisions can be based on physical, that is for example their race, social, such as weak social bonds at school or the amily, biological, that is having genetic abnormalities and psychological factors such as mental health disorders (Pond p. 23).. Through Beccariasââ¬â¢ observational studies witnessed many discrepancies within the government and public affairs, and ostracized the inhumanity and inequality shown to individuals within society, where the punishment of crimes were judged on the social status of an individual (Hopkins Burke 2001). Beccaria believed the ââ¬ËCriminal as Calculatorââ¬â¢ highlighting the importance that every criminal is an individual and is aware of what is goo d from bad, what is right from wrong, understanding definitions of criminal behaviour in society therefore each individual is competent n the calculations that he or she makes, presenting the notion of ââ¬ËFree will Choiceââ¬â¢ and the ââ¬ËHendonistic Calculasââ¬â¢ principle where the distinct actions of an individual are measured through a pleasure and pain scale, with this Beccaria made further contributions towards Benthamââ¬â¢s theory of Ulitiarianism (which is based on the assumption that the ultimate aim of all human activity is happiness), disputing that creating new legislations indicating that a clear law should set out which is easily deciphered by its societal members to understand and set by legislators, Beccaria views that the prevention of crime is better than the punishment, however, punishment must be dealt with swiftly not limiting or exceeding what is necessary for the prevention and deterrence of crime, therefore resulting in the greater happiness o f the majority (McLaughlin and Muncie, 2006), however there should be impartial judges fixing strict punishments in proportion to the seriousness of the crime, for example, petty crimes and theft should be dealt with fixed fines and penalties and more serious crimes administered with corporal punishment and labour (Hopkins Burke, 2009).With this Beccaria developed further studies within the ââ¬ËSocial contractââ¬â¢ theory, the voluntary agreement of the members of an organised society and its government securing mutual protection and welfare regulating the relation among its members, explaining that the previous methods of torture through capital punishment was unnecessary, he deemed these barbaric and inhumane, through this Beccaria began developing ideas that the crime itself should be dealt with efficiently not the criminal, thus the individual should be penalised for the crime committed. Each and every individual member of society whether an abiding member or criminal has equal rights and this always remains.Beccariaââ¬â¢s classical school of thought brought about scholars Bentham (1748) an English juror and philosopher who defensively argued that punishment should be a deterrent for criminals, that penalties be fixed to inflict the sum of pain in surfeit of the pleasure that had derived from the criminal act (Hale, Hayward Wahidin and Wincup, 2005) and Howard (1726) who was influential upon Prison reform (1779), However crime and criminal behaviour continuing to present itself still necessitated explanations as to why crime was still on the uprise Lombroso provided foundations for many other proponents such Ferri (1856), a biologist who wrote a new penal code for Mussolini which was instantly revoked due to his positivist approach and Garofolo (1852). Conclusion References Hopkins Burke, R. (2009) An Introduction to Criminological Theory, (3rd ed. ) Cullompton, Devon: Willan Publishing Hale, C,. Hayward, K,. Wahidin, A and Wincup, E. (2005) Crimi nology, Great Britain: Oxford University Press
High School and College Essay
Many aspects of both high school and college can be tied together. People learn many of the same things they learned in high school during their first year or two of college. They are basic general education classes. They are similar in such ways that you still have to go to class, do class work, home work, take test, and study hard. Depending on the school, teachers can also give you that one on one help. Class sizes can also be similar to high school if you attend a small college. They are both learning experiences that the individual helps write for themselves by their choices and decisions. There are similarities in the people also. Even in college cliques and groups develop, just like in high school. On the other hand, we all know that high school and college are very different. The work in high school is kind of easy. In college, itââ¬â¢s time to strap down and get to work. Thereââ¬â¢s really no room for error. Attendance is very important in high school. If you miss a day in class, the teacher would call home. In college, itââ¬â¢s your own responsibility. Students end up having the same friends throughout high school, because they grew up with them in elementary and middle school. Because of this, they earn an image or reputation. College is a new beginning. People are not tagged with a prior social status or image. It is an opportunity to start new and meet new people. Some people meet many of their lifelong friends in college, because they go through so much together. In a way, they are transferring to adulthood, with them by their side. High school and college are what students makes of it. High school prepares people for college. College is a new chapter in life, and also a new beginning. In a way, college is a mature version of high school. To find the true similarities and differences, people must experience both for themselves.
Tuesday, July 30, 2019
Emotion is not very strong Essay
In this research, the correlation coefficient is +0.0563 and this number is closer to +1. It means these two variables do have positive correlation but just a slight positive correlation. In other words, if one variable is large the other one will tend to be large. However, +0.0563 is not very close to +1 and it does not reach half of 1, so it does not mean the more chocolate people have, the happier they will be. The +correlation can prove chocolate can have a slight positive effect on emotion and when people are happy they would like to eat chocolate to share the happiness. The data in the first three questions proved that most people like chocolate because of its taste, and eat it very often. However there is still 20% of people do not like it and do not eat it very often. By considering the fourth question, half of people think that chocolate could make them feel better when they are sad. It means chocolate does affect emotions, and help people escape bad mood. For the last question, 8 out of 10 agreed that eating chocolate is useful to reduce the stress and make people feel free. There is a research which was done by Gordon Parkey, (School of psychiatry, University of New South Wales), and they wrote the following result:à ââ¬Ë Chocolate can provide its own hedonistic reward by satisfying cravings, but when consumed as a comfort eating or emotional eating strategy, is more likely to be associated with prolongation rather than cessation of a dysphonic mood. Any mood benefits of chocolate consumption are ephemeral.ââ¬â¢Ã So it could be a kind of evidence that chocolate could affect emotion. And it indicates that chocolate has a short-time effect on emotion, but it could not last too long. Summary of analysis:à To sum up, the correlation between chocolate and emotion is positive, but it is not very high. By analyzing the data, chocolate could affect emotion and it may useful to help people to reduce stress and feel free. So the two hypothesizes are correct. However, it has to be admitted that the correlation coefficient is low. So the function of chocolate may be not very efficient for emotion. Conclusion In conclusion, this report uses the survey studies to investigate the correlation between chocolate and emotion.10 questions were made for 10 participants. The correlation coefficient is not very high, and it means although chocolate can affect emotion, it just would be a slight effect. The data indicates that chocolate can help people to be relax and happy.à However, in this research, the correlation between chocolate and emotion is not very strong. The reasons for the low correlation coefficient are various. Firstly, the number of participants is not enough. It is too small to get the general conclusion. Second reason is most of participants are Chinese. Compared with people in western countries, Chinese are not very fond of eating sweets. It is the cultural difference. The third reason is the design of this questionnaire is a little simple, and questions are not enough to investigate such a huge item.
Monday, July 29, 2019
How HR can contribute to CSR Essay Example | Topics and Well Written Essays - 1250 words
How HR can contribute to CSR - Essay Example Current paper aims to highlight the main aspects of the relationship between the human resources management and the corporate governance ââ¬â especially regarding the role of HRM in the development of corporate social responsibility. Reference is made to Humphrey Group and specifically to the firmââ¬â¢s compensation ethics as used for evaluating the compensation of the firmââ¬â¢s top managers. The findings of relevant academic studies are presented and analysed aiming to show that HR can support the development of corporate social responsibility in Humphrey Group ââ¬â as also in firms with different structural and operational characteristics. 2. Human Resources and Corporate Governance 2.1 Influence of HR on Corporate governance ââ¬â modes, consequences The role of HR in corporate governance cannot be doubted. In fact, this role has many different aspects. In all organizations, HR department cooperates with the CEO in order to identify potential breaches of the firm ââ¬â¢s ethical rules. Beatty et al. ... The survey, which was conducted among focus groups, aimed to highlight the level at which ethical standards can interact or opposed with professional practices and rules within modern organizations. One of the most important findings of the above study has been the fact that, quite often, HR managers are asked to serve contradictory organizational needs, or else, to serve interests, which are opposed. These are the interests of stakeholders who are favoured by different organizational initiatives. On the other hand, it seems that HR professionals may not be always aware of their role. Instead, they are informed on the activities and decisions on which their power is justified, i.e. accepted by the Board of Directors (or the organizationââ¬â¢s leader) but they are not aware of their actual capabilities regarding their role. At the next level, the study of Beatty et al. (2003) refers to a quite important issue: ââ¬Ëthe financial measurement and the rewarding systemsââ¬â¢ (Beat ty et al. 2003, p.258) are often poor. In this case, executives need to identify a solution in order to ensure the fairness in their compensation. In most cases, the response of the firms to the claims for compensation, pension and so on, are expected to be negative ââ¬â in case such claim is presented to the Board of Directors. In this context, the intervention of executives in the books of their organizations is often unavoidable, even if it is not legally justified. The most important finding of the survey conducted in the context of the study of Beatty et al. (2003) is the following one: in most organizations, ethical standards are highly promoted. However, in practice the limitation of violation of
Sunday, July 28, 2019
Final paper Assignment Example | Topics and Well Written Essays - 1500 words - 1
Final paper - Assignment Example hat practice stakeholder capitalism do not necessarily promote the interest of shareholders, but rather give reconsiderations to the diverse interests expressed by all the stakeholders (BÃ ©land & Cox, 2011). Stakeholder capitalism allows businesses to focus on long-term economic decision-making. The basis of Stakeholder capitalism is contrary to shareholder capitalism, which focuses on profit maximization. Stakeholder capitalism is common in Germany and Japan because corporate governance does not rely on the rights of private property as promoted in the shareholder model of capitalism. Businesses that rely on Stakeholder capitalism are more likely to have a positive reputation because they make decisions that promote the interests of different parties. De-commodification focuses on analyzing the extent to which social welfare minimizes the market dependence of the people. Therefore, de-commodification can only become a reality when people receive services as their rights without unnecessary dependence on the market. Moreover, the people must be able to sustain a livelihood without exhibiting any measure of dependence on the markets. For this reason, social welfare should ensure that people do not necessarily need to actively participate in market relationships for them to access necessities. Notably, de-commodification promotes the provision of necessities outside the labor market mechanisms. De-commodification has outstanding benefits to workers and individuals because it can raise their collective power. The concept of de-commodification was developed recently, a factor that explains why there is a lack of definitive descriptions of the concept (Hall & Soskice, 2001). However, many people understand the concept of giving citizen s a measure of freedom to quit work without facing risks such as lack of income or loss of jobs. Moreover, the fact that people do not have to rely on labor markets to access necessities promotes their wellbeing. Disintermediation is a
Saturday, July 27, 2019
Does data and analysis present a good argument Debating the research Assignment
Does data and analysis present a good argument Debating the research method of an article - Assignment Example The large size of sample is associated with biasness during presentation due to the work load involve, a confirmation that differences are as a result of size bias not mode selected. Sampling mistake arises in the sampling procedure itself as not all parties of the outline population are assessed (Easterby-Smith et al 2003). Normative model is used during web surveys as opposed to paper and pencil procedures. What I could have suggested for the authors of the article is to reduce the sample size. By using accommodating sample size it is easy to manage the sample bias. Normative model presents an opportunity for participants not to pay much attention as compared to face to face or telephone surveys (Easterby-Smith et al 2003). I would suggest combining normative model with instrumental model to improve sample bias and check ramifications of low response rate (Vieira et al 2002). The research relied mostly on qualitative research rather than employ mixed research method. Vieira, W., De La Tour, K., & De La Tour, S. (2002). Projectiology: a panorama of experiences of the consciousness outside the human body. Brazil, International Institute of Projectiology and
Friday, July 26, 2019
Forces of Globalization Essay Example | Topics and Well Written Essays - 750 words
Forces of Globalization - Essay Example One such force is the dependency of some nations on others, as a result of the increased inequality between such countries. It is clear that some of the countries have developed to world economic powers as a result of their expertise, resources, and technology. On the other hand, most of the countries around the globe are still underdeveloped, with lack of proper technologies and expertise to exploit their resources. From the past, the relationship between these developed and underdeveloped countries has remained one of dependence, with the latter depending on the former for economic and political. In his book, Wright suggested that the Niumi people were dependent on the British during the colonial times and at a point, they remained without basic resources such as healthcare facilities, until they were built by the British. Such is still the case in the current world as the gap between the developed and developing countries has continuously increased, forcing the developing countrie s to develop in the developed countries for financial and humanitarian aid. International politics has also been an interestingly significant determinant of international interactions. Nations from various parts of the world have different political ambitions, some of which are taken into the international environment, leading to either formation of political alliances or conflict. Defined by different political boundaries, different nations are faced with the mandate to protect the interests and sovereignty of their people.
Thursday, July 25, 2019
How effective are services in treating individuals who self harm Thesis Proposal
How effective are services in treating individuals who self harm - Thesis Proposal Example erstandable forms together with redundant risks, continuing in a foul relationship, developing problems similar to anorexia, alcoholic or drugs obsession or somebody merely not concerned with their psychological or bodily requirements. These responses might assist to manage with feelings that intimidate to devastate them with sore emotions for instance fury, depression, meaninglessness, woe, self-hatred, trepidation, isolation and culpability. These are possible to be unconfined throughout the body where they are easily noticeable and treated with. Self-harm could provide a quantity of functions at the similar time. It could be a mode of: In the society the act to self harm is taken as a ââ¬Å"unswerving, communally objectionable deeds that causes bodily grievance where the individual is not trying suicide but is in a sensitively distressed state.â⬠The act of ââ¬Å"Self-harmâ⬠is mainly elicited by an aggressive argument with a close relative or friend. It is been noticed that people comprising excessive mistreatment and ignorance in their life are more prone to harm themselves. This extreme action generally happens following a upsetting incident and is a consequence of lacking abilities to tackle issues in a efficient manner. As per the psychological experts, at times the individual intentionally harming himself believes that their feelings or pain can be expressed in a better way, if they can be seen outside, which might provide a chance to win over the situation and it can prove that physical injuries are a mode to express their emotional pain. Though the substantial pain experienced by them serves as a mechanism that discharges the disturbing pain but it is a undeniable fact that the reprieve they sense is impermanent. These coping methods in quintessence are defective as the pain ultimately returns devoid of any enduring healing. ââ¬Å"When the Body is the Target: Self-harm, Pain, and Traumatic Attachmentsâ⬠ââ¬â In this book the author ââ¬Å"Sharon Klayman
Asbestos Essay Example | Topics and Well Written Essays - 2250 words
Asbestos - Essay Example An estimated 1.3 million employees in the construction and general industry are at risk. No doubt, we are exposed to a certain level of asbestos material all the time. Asbestos, in the finished form, does not pose any health hazard. Remodelling, repair, maintenance, demolition, sale and transport combined with rough handling all can release these deadly fibres into water or air2. Inhalation of these fibres for a continuous period could be extremely dangerous. . Chrysotile, a fibrous mineral which neither burns nor rots, flexible with maximum tensile strength, extremely useful, lightweight, can create a formidable surface mixed with cementing materials, could be used as high temperature seals and gaskets, known over 2000 years, first mined in Russia, Italy and Canada. Old products, unlike today's improved technological ones, crumbled easily under pressure and released more harmful fibres. All these fibres are non-inflammable Asbestos is a highly emotive topic with two shrill schools of thought, one saying that asbestos should be banned; another arguing that asbestos of today would not be a killer. European Union (EU)3 and the United Kingdom (UK)4 both argue that asbestos is carcinogenic and targets multiple organs of the dust inhaler. According to their rules all types of asbestos are harmful and there is no safe level of exposure and the weight of evidence to support this is incontrovertible and historical. It is impossible to control the exposure to asbestos in workplace and hence, alternative products must be used. Asbestos should be discarded as a harmful object and should be banned, to protect public health. This risk-based approach depends on the fact that there is no identified lower exposure limit to which workers can be safely exposed.5 In spite of the overwhelming medical reports, there is little scientific research evidence to back this viewpoint and the entire exercise seems to be more of a public emotional grandstand. Asbestos is heat resistant and is used in a wide variety of industrial and domestic appliances and this makes it particularly difficult to avoid it completely. It is a mineral fibre used in a variety of building construction materials for insulation and it is also a fire-retardant. The necessity of completely stopping the usage too is questioned by many scientists. The Canadian Chrysotile Institute
Wednesday, July 24, 2019
Socio-Economic Profile of a Switzerland Essay Example | Topics and Well Written Essays - 2500 words
Socio-Economic Profile of a Switzerland - Essay Example In the paper, Switzerlandââ¬â¢s status regarding Market Economy and Productivity, Purchasing Power Parity and Human Development Index are discussed. Religion is an important social variable that often determines the associated risk factors with a certain form of business. The religious stubbornness of the people of a country might put many constraining factors on the business environment of that country. By December 2010 the population of Switzerland was 7.9 million (. According to a publicly funded study the foundation of religious belief in Switzerland is eroding at a fast pace. 32 percent of Swiss populations are Protestant and 31 percent of them are Catholics; 12 percent are of non-Christian religion and 25 percent does not have any religious beliefs. Forty years ago the scenario was lot different when only one percent of the Swiss population was bereft of any religious belief. In the year 2000, the same figure stood at 11 percent. Language is the most important form of person al communication. Since in business communicating with people is most necessary, hence having a clear knowledge of the official languages of a country before setting foot upon its soil is most important from the business point of view. The four official languages of Switzerland are German, French, Italian, and Rumantsch. The meaning of body language and etiquette along with corporate culture differs from country to country. Knowing the meaning of the same might make a difference regarding success or failure of a business decision. The Swiss value ââ¬Å"cleanliness, honesty, hard work, and material possessionsâ⬠. The Switzerland motto is ââ¬Å"Unity, yes; Uniformity, no.â⬠The Swiss people are ââ¬Å"proud of their environment and have a long tradition of freedom. They value sobriety, thrift, tolerance, punctuality and a sense of responsibility.ââ¬
Tuesday, July 23, 2019
Grant proposal Research Example | Topics and Well Written Essays - 1250 words
Grant - Research Proposal Example In many instances, these convicted felons are injured while in correctional facilities and due to the lack of funds due to their poor backgrounds, LITTLE Engineers aim at improving the quality of life of such students in correspondence to CCPH aims by restoring their health. The drastic positive shift of this technology influences business, society, and government. We plan to collaborate with other organizations like the Federal Bonding Program, Work Opportunity Tax Credit, and Workforce Investment Act (WIA) that look into the welfare of such students including the University of Houston Graduate College, which will further the skills of the convicted felons. METHODS: The Work Opportunity Tax Credit and Federal Bonding Program help us manage our foundation with the local Houston community center. A family oriented approach incorporated in the rehabilitation process of the convicted felons. As a result, our program has a limited number of individuals, which leaves the convicted felons feeling like a family and embrace the new technologies that build their self-esteem and restores their health. Moreover, the training curriculum incorporated in the program is healthy in terms of preventing the felons from engaging in illegal activities. We have an on-the-job-training environment for technology, information, and training for customer skills. OBJECTIVE: In Houston, the number of convicted felons is rising and is affecting the development of Houston and other major Texas cities. There are programs offered by Houston and Texas governments, but they are not able to accommodate the rising numbers of convicted felons. As a result, our program plans to reach out to 100 students and give them a chance to reach their dreams by restoring their lives and that of their other convicts. The collaborative effort of employees and staff personnel has seen the convicts benefit from the information and skills impacted and offered by LITTLE Engineers. These convicts are the future lead ers and as an organization, we have seen the need to advocate for promoting hard work, commitment, and embracing of new technology in the society. The work ethic and dedication they learn from LITTLE Engineers will help them learn and utilize the knowledge for the rest of their lives. As a result, the lives of both college students and the community will be changed forever. LITTLE Engineers Overview The rise of immoral behavior is a factor that has contributed to the rise of school dropouts in major cities and towns (Marchevsky and Theoharis ). The Federal Bonding Program, Work Opportunity Tax Credit, and Workforce Investment Act (WIA) has been able to team up with the LITTLE Engineers in overseeing the activities of community building through healthy living education workshops. LITTLE Engineers are aware of the need to familiarize students with the technological systems in the medical field and have formed partnerships with other organizations to give rehabilitation services to be able to succeed in the current work environment. Background Convicted felons in the United States have increased at an alarming rate that has brought the attention of many organizations because the health of young people is in jeopardy. It
Monday, July 22, 2019
Milgram Obediance Study Essay Example for Free
Milgram Obediance Study Essay In May of 1962 Stanley Milgram, a Social Psychologist at Yale University, conducted a study on ââ¬Å"Obedience and Human Natureâ⬠that was influenced by his curiosity of the WWII German Nazi Holocaust and concentration camps. Milgram asked ââ¬Å"How could it be, that ordinary German people could allow the extermination of the Jewsâ⬠and wanted to know under what circumstances would a person disobey authority? The study took place in the greater New Haven area and consisted of 40 male participants that were recruited after responding to a newspaper ad. Each participant was compensated for their participation, and were given $4.50. It was thought by many professors that only 3 out of 100 participants might deliver the maximum shock. After the recruitment, Milgram conducted a series of controversial experiments with his invention of a shock generator. The switches were labeled and ranged from slight shock, stong shock, very strong shock, moderate shock, intense shock, extream intense shock, to Danger Severe Shock and the last two only stating ââ¬Å"XXXâ⬠. The voltage began at 30, increasing by 15 volt increments for each switch, all the way up to 450 volts. The purpose of Milgrams experiment was to try and answer,ââ¬Å"How far would you be willing to go?â⬠Prior to the experiment the professor explained the procedure to each participant. The ââ¬Å"Studentâ⬠was hooked up to the shock machine with leads that were connected by a paste that was supposed to protect the skin from being damaged or burned. The proctor explained that the shocks would be painful, but would not cause harm to the subject. The role of the ââ¬Å"Teacherâ⬠was to ask the ââ¬Å"Studentâ⬠a series of questions. With each wrong answer the ââ¬Å"Teacherâ⬠was to deliver a shock to the ââ¬Å"Studentâ⬠. However, what Milgram did not reviel was that the study was in fact, rigged. The ââ¬Å"Studentâ⬠had been given a script, and was instructed to pretend to be shocked. During the experiment, with each stagged wrong answer, the ââ¬Å"Studentâ⬠complained about the pain. As the intensity increased, the ââ¬Å"Studentâ⬠began to complain about having heart problems. Begging for the ââ¬Å"Teacherâ⬠to stop. Pleading and demanding to be let out of the room over and over again. All the while the ââ¬Å"Teacherâ⬠was prompted by the proctor to continue. Throughout the exam, most of the ââ¬Å"Teachersâ⬠began to doubt if they should continue. Asking the proctor ââ¬Å"how far should I goâ⬠, or ââ¬Å"what will happen if I continueâ⬠. Each time, the proctor would encourage the teacher to ââ¬Å"please continueâ⬠telling them ââ¬Å"you have no choice but to continue, the experiment depends on youâ⬠. With each shock the ââ¬Å"Teacherâ⬠became increasingly agitated. Demonstrating mental anguish, and struggled with the their emotions of inflicting pain with the next shock. Eventually after hitting the 300 volt mark the ââ¬Å"Studentâ⬠got to the point that he stopped responding to the questions. By this point the ââ¬Å"Teachersâ⬠were angry and refused to continue. The proctor advised the ââ¬Å"Teacherâ⬠to treat the silence as a wrong answer and instructed to proceed with the experiment and to administer another shock. This caused increased severe mental anguish and suffering on the ââ¬Å"Teachersââ¬Å" behalf. Some would refuse again to continue, stating that they ââ¬Å"wouldnt go on if I thought I were harming themâ⬠. One even shouted, ââ¬Å"Im not going to be responsible, Im not going to kill the man.â⬠The proctor simply responded, ââ¬Å"you have too, you have no other choice but to continue.â⬠Many of the phrases used to prompt the ââ¬Å"Teacherâ⬠to continue included, ââ¬Å"The experiments require you to continueâ⬠, and ââ¬Å"Its absolutely essential that you continue.â⬠The results of the Milgram experiment tested his theories of why people were willing to go against their conscious and demonstrated just how far people were willing to go to stay in compliance with an authoritative figure. In 1974 Milgram published his book ,ââ¬Å"Obedience to Authorityâ⬠which raised controversial, ethical, and moral issues of his experimentation on Obedience. Many believed that it was cruel and several professors stated it was ââ¬Å"in humaneâ⬠and questioned his use of human subjects, due to the cruel nature that caused mental anguish, unnecessary stress, grief, and turmoil on the so called ââ¬Å"Teacherâ⬠. After the experiment, Milgram purposed the question, ââ¬Å"Why did so many agree to and perform the shock treatment, if they felt it was wrong?â⬠I believe that there are many factors that influenced the participants to continue to deliver the shock treatment, some of which include the following; 1. Human nature to be pleasing. I believe that Authority is seen to be powerful and insurmountable and having the authoritative figure presence, tromping them to continue even when they wanted to stop had a huge influence on the participants and affected the ââ¬Å"teachersâ⬠decision to continue even though they wanted to stop. 2. Fear of non-compliance. I believe the participant felt an obligation to continue because of the agreement they made with the University to participate. I think that some may of thought their might be consequences if they disobeyed the proctor. 3. Curiosity and sadistic behaviors. I think that some participants wanted to see just how tolerant the ââ¬Å"Studentâ⬠could be. 4. The experiment was held at the highly esteemed Yale University. I believe this peeked the interest of the participants and many wanted to be a part of a highly accredited institutional study group. 5. Many believed it was safe. They were told that it was not dangerous, it was painful but would not harm the participant receiving the shocks and this allowed the participants to continue administering the shocks because they trusted what they were told. 6. Ability to redirect responsibility onto the Authoritative figure, in order to relieve the guilt they may feel- stating ââ¬Å"I was only following orders.â⬠I found the results of the Milgram Obedience study astounding. Of the 40 participants, 26 delivered the maximum shock and 14 participants stopped at various levels throughout the experiment, siting they ââ¬Å"just couldnt go on.â⬠While watching the video, I found myself feeling anxious, and thought about how I would of reacted. The Milgram experiment demonstrates exactly how people actually react when placed in certain circumstances, rather than a hypothetical situation, stating how they feel they would react. I believe this study revels how some humans can detach themselves emotionally in order to remain obedient. So after thinking about the statistics of the experiment I shouldnt have been so surprised that 65% delivered the maximum shock. I would of never believe so many of them would have gone thru with the experiment and felt that the number would have been much lower. There are many examples throughout history of how dangerous it can be to take obedience to the extrema. One example is during WWII. The Germans treatment of the Jews was horrific and unimaginable. It was estimated that during the Holocaust, the Nazis used the concentration camps to murder approximately 11 million people. So you ask, yourself, how could such a horrific event take place?, How could people be so EVIL? These conditions were real and the answer to these questions are highly debated throughout the world by Psychologist, Analysis, Universities and amongst people sitting at dinner tables everywhere. It lies deep within the dark places of evil minds. It unleashes its wrath and destroys. In conclusion, I believe we are taught to be obedient from birth. As parents we teach our children to obey us, so that they learn consequences and grow into respectable, responsible adults. God expects us to obey his commandments. Police officers expect us to obey traffic laws. Employers expect us to obey rules and regulations, and office policies On a daily basis we are told to follow instructions, directions, commands and orders. Obedience involves power and status and is influenced by social pressure and conformity. As a society we are conditioned and expected to be obedient.
Sunday, July 21, 2019
Oncolytic Virus Therapy for Cancer
Oncolytic Virus Therapy for Cancer Abstract Interest of oncolytic virotherapy is mounting from over the past few decades for treating many kinds of malignancies. Despite oncolytic viruses attain many successes in cancer therapeutic era; they all have still challenges in their developments. The interaction between virulence factors of viruses, hosts immune defense system, microenvironments and tumour factors are the hazardous influences in their achievements of novelties. Currently, with the thanks of modern recombinant biotechnology, most of the oncolytic viruses are increasing their tumour selectivity and specificity. On the other hand, they reduce their efficacies on physiologically functioning cells. Furthermore, combinational therapies with traditional anti-cancer treatment regimes have also promising and relevance outcomes. In 2004, Chinese food and drug administration (FDA) approved first oncolytic virus in treatment of head and neck tumours. However, they have some still unsolved obstacles in proper cancer therapy. In m y paper, the current issues and future prospects of the oncolytic viruses are highlighted how to use as therapeutic weapons. Keywords: Oncolytic viruses; Oncolytic virotherapy; Cancer gene therapies; recombinant 1. Introduction Cancer is one of the leading causes of death globally comprising 13% of all deaths (7.6 million deaths) in 2008. Although well established conventional therapies including surgery, radiotherapy and chemotherapy are existed, we still need new therapies and strategic plans. Local therapies such as surgery and radiotherapy have been limited in disseminated tumours. Likewise, chemotherapy has some intolerable adverse effects and sometimes, pre-existing chemo-sensitive tumours are resistance to chemotherapy after prolonged used. Thus, we really need certain promising therapies to handle these problems. Recent years, oncolytic virotherapy is uprising and promising for the various types of cancers. Ideology of virotherapy treating the malignancy has been introduced since early 20th century. However, since early oncolytic viruses were targeted not only tumour cells but also the normal cells, interest in the virotherapy was declined. Therefore, many trials related with such therapy were termi nated during the following decades. Late 1990s, interest of virotherapy was re-active with the advance of modern biotechnology. Today, concern of the virotherapy is high and it has the potential promises as a reasonable cancer treatment by itself or conjunction with other conventional therapies such as surgery, radio and/ or chemotherapy (synergic effect). Advance technology allows the development of oncolytic viruses which only effective on dividing cancer cells but not attack the normal dividing cells. There are generally two types of oncolytic viruses namely non-engineered (naturally occouring) and engineered agents. Both types may destroy the malignant cells without harming the normal cells. Generally, oncolytic viruses only infect and preferentially replicate within the cancer cells followed by lyses these cells. In recent years, many therapeutic virus candidates are emerging and testing their oncolytic prosperities with preclinical and clinical trials. Among them, adenovirus H101 was the first virus approved by C hinese food and drug administration (FDA) in 2004 as the adjuvant oncolytic virotherapy combined with pre-existing conventional chemo- and radiotherapy in the head and neck cancers. 2. Type of oncolytic viruses Oncolytic viruses are principally divided into 4 types according to their mechanisms of action. There are intrinsically tumour selective viruses, virulent gene deleted viruses, promoter inserted viruses and pseudotyped viruses. Genetic modified oncolytic viruses are manipulated whether insertion of the transgenes or deletion of the virulence genes. Naturally occouring tumour selective viruses are the viruses that are not genetically modified, direct targeting on the malignant cells. For instance, New castle disease virus, Vesicular stomatitis virus, Poliovirus and Reovirus are intrinsically tumour selective. However, affectivity is less due to depend on the natural strength of their lytic properties. Virulent gene deleted oncolytic viruses are more popular because their selectivity on target tumours are more specific without infectivity to normal ones. For example, herpes simplex virus, adenovirus, measles virus and vaccinia virus can be modified by deletion of their virulence protein coding genes. In addition, inserting of foreign genetic elements such as promoter region boost tumor specificity and selectivity of oncolytic viruses. Thus, tumour cells allow the replication of these viruses because only tumour cells can activate the promoter region of them. For example, prostate specific antigen (PSA) promoter inserted adenovirus CG7870 applies in prostate cancer and promising results were came out. Pesudotyped oncolytic viruses are modified with ligands which target tumour selective cell surface receptors. Therefore, they solely have their infectivity on malignant cells. (E.g. adenovirus delta 24RGD). Moreover, these viruses may reduce toxicity and dose requirement. 3. Characteristic features of standard oncolytic virus Since viruses can infect not only the malignant cells but also the functioning cells, oncolytic virotherapy is the critical therapy. Hence, safety and efficacy of the virotherapy are considerable issue and still challenging for further improvement. Potential oncolytic viruses are needed to confirm or compare whether they have real ideal characters of oncolytic virus or not. Standard characters of the oncolytic virus stated that (1) they only replicate within tumour with high multiplication rate, not on normal cells (2) less or no infectivity and virulence than their wild types (3) genetically stable so that mutations and recombination with other viruses are minimized for manufacturing and safety issues. DNA virus is more stable than RNA virus (4) can inactivated anytime with antiviral drugs or other mechanisms (5) considerable mass production (commercially available) can be possible with good manufacturing practices. Therefore, for development of virotherapy, all oncolytic viruses sh ould be fulfilled above criteria. Adenovirus and Herpes simplex virus (HSV) have high selectivity and specificity on tumour cells with massive replication rate of 1000 folds in 1st cycle. Besides, they are considerably stable whereas terminate anytime with their respective antiviral therapy (e.g. adenovirus is self-limiting and HSV is treated by acyclovir). 4. Tumour selective mechanism With the knowledge of the malignant cells molecular biology, oncolytic virotherapy can be created to attack the tumour cells selectively. Cancer cells undergo changes ranging from subtle point mutation to chromosomal instability. Inherent tumour selective viruses specifically attack the tumour cells by targeting the specific tumour promoting pathway of the malignant cells such as activated Ras and AKT pathway, defective interferon (IFN) pathway etc. RNA-activated protein kinase (PKR) pathway is a natural process that inhibits viral protein synthesis. Physiologically, interferon (IFN) secreted from infected cells phosphorylates the PKR which subsequent phosphorylates eIF-2à ±. Then, phosphorylated eIF-2à ± interfere the oncolytic viral protein synthesis that require for their virulence. In contrast, Ras mutation and defective IFN in malignant cells disturbs the PKR pathway and favours the oncolytic virus activity. For instance, herpes simplex virus (HSV) containing neurovirulence gene à ³34.5 that binds with intracellular phosphatase and dephosphorylates eIF-2à ± allowing replication of HSV in both normal and tumour cells. However, deletion of this gene permits to replicate only in Ras mutated or interferon (IFN) defective cells. Controversially, recent finding suggested that à ³34.5 deleted HSV can also replicate in PKR functional malignant cells. It is seen to be defects in PI-3 kinase pathway which favours translation of à ³34.5 mutant HSV. Moreover, genetically modified adenovirus (dl331), VAI mutant strain, prefers to replicate only in tumour cells with Ras activation. Similarly, dl331 is also effective in Epstein-Barr virus (EBV) associated tumours such as nasopharyngeal malignancy because Epstein-Barr virus expresses viral associated RNAs (VA RNAs) that defect PKR pathway. Many cancer cells over-express receptors for virus in high level. Thus, exploiting this mechanism, many oncolytic viruses are selectively homed in their specific malignant cells. For example, over-expression of intracellular adhesion molecule 1 (ICAM-1) and decay acceleration factor (DAF) in tumour favours to infect Coxsackie virus A21. Besides, Newcastle disease virus (NDV) binds sialic acid receptors. Alpha virus similarly uses heparin sulphate or ICAM-1 as its receptors. Both of them are highly express in tumor population. Therefore, these viruses are highly concentrated in tumour cells. 5. Immunogenicity of virotherapy Likewise as many other viruses, oncolytic viruses also stimulate and activate the body defense mechanisms including innate as well as adopted immunity. These viruses produce the viral proteins required for their replication within tumour cells. These proteins also stimulate the MHC class I gene to present it on the cellular surface of tumour cells as well as on the normal cells. MHC class I antigen was recognized by cytotoxic T cells (CTLs) or CD8+ cells which may destroy any cells representing MHC I antigens. Therefore, nature immunity allows eliminating both tumour and normal non-dividing cells. So, oncolytic viruses may also destroy normal cells apart from abnormal ones. An immune mechanism on the oncolytic viruses is one of the major constraints for developing modern virotherapy. However, to date, genetically modified viruses can only replicate and lyses p53 mutant cells. They cannot inactivate p53 gene of the normal host cells. p53 is functional and prevent replication of these viruses in the normal host cells. So, they are allowed their functions only in mutant tumour cells. 6. Conversion of oncogenic to oncolytic Many oncogenic viruses are potential to use as oncolytic therapy nowadays after genetically manipulation. Generally, 15-20% of the carcinogenesis is contributed by various kinds of oncogenic viruses such as herpes papilloma virus (HPV), Epstein-Barr virus etc. Reversely, these viruses can be changed to treat the malignancies by exploiting their lytic effects on the dividing cells. One of the classical examples is herpes simplex virus type 2 which is ongoing trials in many tumour cell lines by deleting its oncogenic genes coding thymidilase kinase or ribonucleotide reductase. Therefore, even tumourogenic agents can be used as oncolytic therapy by engineering their oncogenic gene components. 7. Novel oncolytic viruses 7.1. Adenovirus Adenovirus is interested in treatment of brain tumour especially in glioma multiforme. This tumour is never metastasized and contributed as single lesion. Moreover, it is almost resistance to systemic therapy because of blood-brain barrier and lack of cell mediated antigen drainage. However, fortunately, oncolytic viruses can replicate and spread within the tumour population since blood brain barrier create immune privileged site. In glioma cells, tumour suppressor gene (Rb) is inactivated and lack of expression. Taking this advantage, genetically modified adenoviruses are constructed by deletion of eight amino acids in Rb binding region of E1A protein. Therefore, they are unable to replicate in the normal cells because viruses cannot inactivate Rb gene of the functioning cells. But they can easily divide within the malignant cells owing to the lack of Rb protein. Additionally, adenoviruses induce autophagy in infected cells (malignant cells) through down-regulation of AKT/TOR pathwa y. Many genetically engineered adenoviruses are still on trials including in vitro and in vivo tests. ONYX-015 (dl1520) is a simple adenovirus lack of E1B 55K protein which do not replicate in the normal cells. So, they only express their functions in p53 mutant cells. In other word, their function does not work in p53 competent cells. Onyx-015 is a first oncolytic virus that has been approved by china FDA to treat the head and neck cancers especially refractory nasopharyngeal cancer combining with standard cisplatin based chemotherapy. Onyx-015 should be given intratumoural or peritumoural injection because of their side effects (e.g. flu-like syndrome). In addition, it showed 50% response rate observed in phase I and II clinical trials of pancreatic cancer. Recent studies found that Onyx-015 replication is not solely dependent on p53 function. Onyx-015 can replicate within some p53 competent cells whereas sometimes, cannot replicate even in mutant p53 cells. It may think to be reliable on E1B 55K independent nuclear late mRNA export of the tumour cells but not in functionally norma l cells. Besides, other co-founding effects should be considered. For example, increasing the temperature (fever, hyperthermia or drugs) promotes replication of E1B deficient adenovirus in the malignant cells rather than normal ones. dl250 mutant strain is engineered by deletion of E1B 19K which is homologue of Bcl-2 and also inhibits pro-apoptotic protein Bax. Functionally, Bcl-2 is the anti-apoptosis protein. Hence, deletion of E1B 19K leads to permit cell death in Bcl-2 over-expressed tumour cells. It may also reduce expression of anti-apoptosis proteins and various growth factors. This type of virus is more potent in anti-tumour activity than dl1520. Delta 24 (dl922-947) adenoviruses are genetically modifying agents which are deleted the gene related with virulence factors and upregulate the transcription elements sensitive to the transcription factors of tumour cells. E.g. Delta-24 is modified by deleting of 24 nucleotides (pRb binding region) in E1A gene so that it is unable to inactivate Rb gene in the normal cells. So, it can only effective in the malignant cells. Now, many studies promise that it has potent anti-tumor effect in glioma. E1A mutants are more superior in oncolysis than E1B strains in vivo and vitro. Besides, Delta-24 RGD is more efficient in treating the low CAR (coxsackie-adenovirus receptor) expression malignant cells such as glioma and bronchogenic carcinoma cells. 7.2. Herpes Simplex virus First herpes simplex virus (dlsptk) as an oncolytic agent is developed in 1991 that is deleted in thymine kinase (TK) genes required for nucleic acid metabolism. Lacking of this gene, Herpes Simplex virus (HSV) lose its ability of replication in the normal cells. Hence, HSV only prefer to infect the tumour cells. HSV is a primarily potential treatment in several paediatric cancers including brain tumours. So far, à ³34.5 deleted HSV are tracking on the clinical trials. These all vectors directly target to the tumour cells by deletion of neurovirulant gene à ³34.5 (30kb) which is not essential for replication of the malignant cells. G47Ãâ HSV virus is derived from G207 parent virus. They are constructed by deletion of both copies of à ³34.5 gene (1kb) and deletion of 312bp in ICP47 gene increasing oncolyitc efficacy. Also, they promote MHC class I expression in the tumour cells enhancing the immunogenicity of these cells. G207 variant was completed phase I study in glioblastoma multiforme resulting with no serious side-effects. Similarly, HSV 1716 is a genetically engineered variant by manipulating HSV1 stain 17 and deleting both copies of neurovirulent gene, à ³34.5. Pilot study has already completed in Metastatic melanoma. NV 1020 (R7020) stain is the chimeric recombinant of HSV 1 and 2 with deleting one copy of à ³34.5 gene, UL24 and 56 genes. Originally, it is developed as HSV vaccination. However, recently, it is still ongoing phase II trial on hepatic metastases of colorectal cancer by direct infusion into the hepatic artery. OncoVEXTM is recombinant vector with deletion of à ³34.5 gene as well as ICP47. Deletion of à ³34.5 reduces intrinsic neuro-pathogenecity of HSV whereas ICP47 deletion restores MHC class I presentation. Additionally, insertion of GM-CSF gene stimulates immune response of the host to the tumour cells. Releasing of GM-CSF promotes recruitment of dendritic cells for tumour specific response. It promotes tumour specific antigen (TSA) expression as well. Thus, OncoVEXTM affects not only on local tumour but on metastases or distant tumours. Currently, OncoVEXTM improved loco-regional control of head and neck cancers combining with chemo-radiotherapy. Intralesional injection of OncoVEX GM-CSF is ongoing phase I trials on cutaneous metastases and melanomas although it has dose related limitation such as injection site inflammation. Another advantage is that it is able to carry large transgenes up to 150kb. It is the main advantage of these viruses using for oncolytic agent although they ma y produce neurotoxity at high doses, difficult cloning and reactivate latent herpes infection which are hidden in the nervous systems (Ganglions). 7.3. Newcastle disease virus Newcastle disease virus (NDV) is paramyxovirus containing single stranded RNA which causes Newcastle disease in avian (birds). Earliest NDV (73-T strain) has been started to use as a clinical trial oncolytic virus for cervical cancer in 1965. Based on their oncolytic properties, NDV is divided into lytic and non-lytic stains. Lytic strains direct lyses the targeted cells. Currently, 2 lytic strains of NDV are ongoing trials which are NDV-HUJ and PV701. Both are naturally occouring live attenuated viruses. As NDV-HUJ strain is a neurotropic virus, it applies in glioblastoma multiforme (GBM). Likewise, NDV-PV701 strain has effect on many types of tumours. Results of their trials have potential promising. One of the advantages of NDV is that it selectively replicates in the tumour cells, not on normal ones. When NDV has also studied in breast cancer patients neoadjuvant with chemotherapy, outcome was desirable with minimal adverse effects including fever, flu-like syndrome, hypotension etc. Occourance and severity of side effects is reduced in subsequent therapy due to development of NDV antibodies in patients serum. On the other hand, non-lytic strains disturb the malignant cell metabolisms leading to allow regression of the tumours. Common non-lytic strains include Ulster stain. NDV damages the malignant cells by either direct lysis of the cells, induction of cytokine production (Interferon, Tumour necrotic factor) or enhance apoptosis including both intrinsic and extrinsic pathways. 72-T stain induces cytokine release while Ulster stain over-expresses the TRAIL receptors on tumour cells surface which may lead to apoptosis. 7.4. Mump virus and Simian virus Mump virus is the first paramyxovirus trying to treat in variety of human malignant cells. Vaccine strain 79 (S79) has potential promising oncolytic virus because S79 can only be infected to the cancer cells but not in normal ones. Studying in nude mice, mump virus demonstrated its tumour inhibition effect significantly. Simian virus is also a rubulavirus and among them, strain 5 can be genetically engineered as an oncolytic virus. This modified strain is able to attack several different cancer cell types significantly. 7.5. Vesicular stomatitis virus Vesicular stomatitis virus (VSV) is only rhabdovirus potentially using in cancer therapy. VSV is a single stranded RNA virus considering for oncolytic therapy. Developing of the recombinant VSV virus in 1995, the role of VSV is amounting in virotherapy. In recent studies, genetically modified replication competent VSV prolonged survival of hapatocellular carcinoma, breast cancer and malignant melanoma. Oncolytic properties of VSV is more effective in type I interferon (IFN) resistance malignant cells. Tumour cells are defect in interferon (IFN) signaling pathways but activated in Ras -ERK pathway. However, VSV can also impact on the normal cells especially in high doses. Thus, early (prophylactic) interferon therapy is required concomitant with VSV virotherapy because interferon appears to prevent the viral replication within the normal cells. Using the advantage of replication within the interferon defect cells, recombinant VSV deltaM51 which is defective in M (matrix) protein (poin t mutation) was constructed. Matrix protein is the regulator protein that increases replication and transcription of the virus but blocks the host cells anti-viral mechanism. Studies showed that VSV deltaM51 strain has beneficial role in glioma cells xenografted nude mice. Furthermore, VSV shutdown the blood supply to the tumour leading to deprivation of oxygen and nutrients which may require for tumour growth. 7.6. Measles Measles as oncolytic therapy is more interesting since there was significant regression of Hodgkins lymphoma after infecting with measles virus. Resent study suggested that recombinant measles virus (Edmonston B strain) showed significant inhibition on xenograft SCID mice with human lymphoma cells. Next, Edmonston B stain specifically attracts CD 46 cell surface receptors that are highly expressed in human mesothelioma cells. Thus, this strain has highly attractive role in treatment of mesothelioma. In addition, engineered measles virus with interferon (IFN) à ² gene inhibits tumour angiogenesis rather than parental strain. Despite most of the people previously encountered with measles infection or vaccination in their early life which may cause therapeutic failure, the evidence highlighted that replication of measles virus was taken place even in the immune individuals. It seems to be immunosuppression due to cancer itself or concurrent use of other anti-cancer therapies such as ra diotherapy, and (or) chemotherapy. 7.7. Poxvirus Vaccinia virus (VV) is the most potential candidate poxvirus utilized as virotherapy recently. This virus is genetically engineered by deletion of thymidine kinase genes like herpes simplex virus (HSV). For instance, JX-594 strain which is transfected with GM-CSF gene, displayed oncolytic activity in animal models. However, it may rarely affective in the normal cells. Most Vaccinia viruses kill the targeted malignant cells by apoptosis as well as traditional mechanisms. Myxoma virus, another poxvirus, is significantly effective on human glioma cancer cell lines. In addition, rapamycin (immunosuppressant) reinforced its oncolytic efficacy when using combination. 7.8. Togaviruses Togaviruses (Sindbis and Semliki Forest Virus) also show their potential roles in the oncolytic therapy. Sindbis virus (SIN) is an RNA virus that naturally infects human by mosquito bites. This virus binds with its receptors of 65kD (Laminin receptors) which are highly express on the tumor cells (tumour homing property). To take the advantage, Sindbis virus promotes considerably regression of the several tumor cell lines in vitro testing and xenograft SCID mice. In human study, it has promising effect on cervical and ovarian malignancies with minimal or no remarkable adverse effect on normal cells. Next, Semliki Forest Virus (SFV) may inoculate repeatedly without prominent immune response. Togaviruses favour as the oncolytic virotherapy agents due to their high replication rate, broad spectrum of host ranges, increase transgene expression and stable in blood stream. Apart from these viruses, Venezuelan equine encephalitis virus (VEE) is also a replication competent virus which is int eresting in certain circumstance of oncolytic therapy. 7.9. Retrovirus Gamma retrovirus (moloney murine leukemia virus (MoMLV)) may have effect on the tumour cells not in the non-dividing cells. So, it may safe as oncolysis. For instance, when U87 glioma xenografted nude mice were administrated with MoMLV, significant oncolytic result has been reported. These viruses are less effect on normal cells due to lack of nuclear transport of viral genome. Certainly, they cannot replicate well within non-dividing cells. In addition, modified MoMLV viruses expressing HSV thymidine kinase (TK) have synergistic effect on glioblastoma cells combining with ganciclovir (anti-viral agent for HSV). Another retrovirus such as fomy virus has also intrinsic oncolytic property. It is researched recently on glioma implanted nude mice. However, the result is still controversial.
Oman Cement Company
Oman Cement Company Oman Cement Company (SAOG) was formed in 1978. Rusayl Cement plant was completed in 1983 with an annual integrated cement production capacity of 624,000 tons, of cement. In 1999 clinkering capacity expanded to a total of 1.2 million tons per year. The second production line came on stream in mid 1998. Presently the company is working on expanding the capacity of plant form 1.26 MTS per year to 1.70 MTS per year by upgrading production line No. 1 and No. 2. The company facilities are: 1- Computerized Manufacturing Oman cement manufacturing process is fully computerized. This avoids major hazards in manufacturing and needs less manpower. 2- Central Laboratory The Quality Control is supported by central laboratory consisting of robotics, X-ray spectrometers, laser particle size analyzers and computerized physical properties testing equipment. 3- Quality Management System and Environmental Management System oman cement Quality Management System is in accordance with the Quality Assurance Procedures of ISO 9001 : 2000 certification. 4- Pollution Control. The Oman cement company produces many types of cement which are: 1- Ordinary Portland Cement: It is type I Portland cement. Its uses are reinforced concrete buildings, bridges and railway structures. The typical compound compositions of this type are: 55% (C3S), 19% (C2S), 10% (C3A), 7% (C4AF), 2.8% MgO, 2.9% (SO3), 1.0% Ignition loss, and 1.0% free CaO. 2- Sulphate Resistant Cement: It is type V, is used where sulfate resistance is important. Its typical compound composition is: 38% (C3S), 43% (C2S), 4% (C3A), 9% (C4AF), 1.9% MgO, 1.8% (SO3), 0.9% Ignition loss, and 0.8% free CaO. 3- Moderate sulphate resistant: It is type II cement. This type of cement can be used in structures of considerable mass, such as large piers, heavy abutments, and heavy retaining walls. Its use will reduce temperature rise especially when the concrete is subject to hot weather. Its typical compounds composition is: 51% (C3S), 24% (C2S), 6% (C3A), 11% (C4AF), 2.9% MgO, 2.5% (SO3), 0.8% Ignition loss, and 1.0% free CaO. 4- Oil Well Cement Oil well cement, used for oil wells grouting, usually made from Portland cement clinker or from blended hydraulic cements. It is used for cementing work in the drilling of oil wells where they are subject to high temperatures and pressures. Its typical compound composition is: MgO: 6.0% SO3: 3.0% Loss On Ignition: 3.0% C3S: 48%-65% C3A: 3.0% Insoluble Residue: 0.75% C4AF+2C3A: 24% Production methods: There are four stages to produce cement that Oman cement using which are: 1- Preparation of the raw material at quarries 2- Heating and cooling to produce clinker 3- Preparation of the cement 4- Cement packing Process description: 1- Preparation material at quarries The raw material contains of limestone (80% of raw material), silica, aluminate and iron ore. The quarries located around the Oman cement plant. At quarries the raw materials are extracted with heavy equipments. Then the limestones are crushed with mobile crushers connected with long conveyer belt to transport them to storage passing the auto lab to analysis the samples with x-ray each two hours. After that the raw material are moved to reservoirs. Then they are moved with conveyor belt to the raw mill to grind the raw materials. Finally the grinding raw materials are moved to mixture reservoirs to get proper mixture before fed them to kiln. 2- Heating and cooling to produce clinker The raw materials are moved to channel, where heat exchange is occurred between these material and the raising hot gases from kiln, then the materials are separated from the gases. After that the material moved to calciner where the limestone is converted to calcium oxide, and then the calcined materials arefed to the kiln where the temperature about 1400 c and then leave from kiln to get clinker. Then the clinker leaves from kiln to air to reduce its temperature to 100 c to be ready to be moved to cement mill. Kiln process 3- Preparation of cement The clinker that came out of the cooler will be transported by the bucket chain conveyor to the silo. The bag filter on the top of the silo is sized for the feeding by the bucket chain conveyor and thermal air expansion in the storage. The clinker extracted from the silo is transported by belt conveyors to the cement proportioning. The gypsum is added to the clinker. Then the proportioned materials are conveyed via belt conveyor to cement grinding. Materials ground by ball mill are transported separator by bucket elevator. The coarse particles separated return to ball mill for regrinding while the fine product is collected by the bag filter behind the separator and then conveyed to cement silo with an air slide and bucket elevator. Cement silos is used to store the cement. Cement mill 4-Cement packing The cement from extraction systems under the cement silo is delivered to the buffer bin by air slide and the bucket elevator and vibrating screen, before being fed into each packer. The bagged cement can be loaded directly or stored in storehouse temporarily. Machinery and Equipments: No. Name function 1 Limestone Crusher used in stone quarry to crush limestone 2 Clay crusher used in stone quarry to crush clay 3 Limestone Stacker Used to move limestone to preblending stockpile 4 Limestone reclaimer Used to take preblended mixture from preblending stockpile 5 Coal and iron ore Crusher Used to crush additive materials 6 Coal and iron ore Stacker Used to move iron ore to conveyor belt then to proportioning station 7 Coal iron ore reclaimer Used for reclaiming all additive materials and coal 8 Raw mill used for raw materials grinding and drying 9 Raw mill fan Used to adjust the mill inlet temperature. 10 Preheater fan used to dry the raw materials 11 Preheater and precalciner Preheater used for preheating and partial decarbonation, and precalciner for calcination 12 Rotary kiln used to raise raw materials to a high temperature 13 Grate cooler Used for quenching 14 Cement mill Used to grind cement 15 Bag filter Used to collect dust 16 Coal mill Used for coal drying 17 Bulk loader for truck Used to load the bulk 18 Cement packer Used to pack cement product Quality control system: The quality control department in the Oman cement company function is to monitor product quality in every stage of production starting with extracting the limestone from the quarry till the stage of cement mills, by taking samples and analysis them. 1- The computer and x-ray analysis: The automation lab consists of robot, x-ray spectrometers, laser particle size analyzer and computerized physical properties. The samples will be taken by an automatic sampler from a point between the raw mill and homogenizing silo and then transported manually to the central auto lab, where it will be semi-automatically prepared and sent to an X-Ray analyzer. The results analyzed will be sent to a proportioning computer. The computer will calculate the ratio of raw materials and send out the set value to constant feeder according to the chemical compositions and raw meal module required. 2- Physical analysis: To test the fineness, soundness, setting time, strength, specific gravity, heat of hydration and loss on ignition of the cement to achieve the American specifications requirement. Maintenance procedure: The department functions are: -Checking all machinery and equipments are work properly. -Scheduling and planning for preventive maintenance, predictive maintenance. Coordinating with all departments for daily problem. Planning, coordinating of preventive and breakdown activities for achieving high plant availability to meet production target. The procedure that the Oman cement follows in case of breakdown, preventive and shutdown maintenance are: 1. Breakdown maintenance In case of any breakdown maintenance in the production department, they give information regarding the breakdown to the maintenance department, and maintenance workers are sent to the production plant to fix machine failures. 2. Preventive maintenance here, a team of maintenance workers is sent directly to the production plants to check out whether there is any failure in the machinery or not. 3. Shutdown maintenance When the plant is shut down the employees in the production department sent a letter to the maintenance department and successive steps are taken by maintenance department to solve the failures. The plant shutdown occurs every 6 month in March and September. The process of operating and monitoring production lines and machines instantly, so they can watch the failure and damage of the machines and equipments to repair them or replace them. Technical management The technical management responsibility is to supervise all the mechanical, electrical things and maintain the various equipments and everything that related to maintenance procedure, and this management divided in many sections: a- The machine section The responsibility of this section is prepare emergency and planning schedule and do it to all the equipments and report it to diagnose the unusual failure and fix it. Inspect the machinery, check with drawings and specifications and rectification. It contacts with store section to provide the required replacement parts and also contacts with other sections to maintain the equipments at the workshop. At the workshop they fix the equipments in emergency conditions, check the equipments if they work properly and routinely, takes care the equipments and help to clean them. b) The machine operation section The responsibility of this section fabricate the replacement parts, make an order outside the company to get new parts, lathe the machine parts the required the workshops. c) The immediate machine maintenance section The responsibility of this section is to check and fix the production lines. d) The electrical section The electricity department is responsible to repair and ensure the continuation of the work of all electrical and electronic equipment and precision instruments on the production line and also supervises contact with other sections to that the electricity working properly.
Saturday, July 20, 2019
Mary Stuart, Queen of Scots Essay -- Biography
Mary Stuart, Queen of Scots She became queen when she was only 6 days old. She was sent to France at age six to get married. She is the cousin of Queen Elizabeth I. Who is this elegant, yet struggling woman? Mary Stuart, Queen of Scotland. Beautiful and brave, Mary Stuart was known for being the Queen of Scotland, France, and was in line for the throne of England and she was also considered the true queen of England. Mary Stuart was born on December 8, 1542, in Lithingow Palace, Scotland. She was the daughter of King James V of Scotland and Mary of Guise. Her father died only six days after Mary was born, so she became Queen of Scotland when she was only six days old (Haws Early Life par 1). She was crowned on the ninth of September the following year at Sterling. Mary was christened in the Parish Church of St. Michael, near the palace (ââ¬Å"Mary, Queen of Scotsâ⬠par 1). Later, when Mary turned six, she was sent to France by her French mother for her protection. While she was there, she lived as the French royal family (Haws Early Life par 1 and 2). When she set off to France, she traveled with the Children of Scotlandââ¬â¢s Nobility, which included the Four Marys. They are the women who would stay with her throughout anything (ââ¬Å"Mary Queen of Scots Bioâ⬠par 5). They were also educated at the French court with Mary, where she was brought up. During her stay in France, King Henry gave Mary precedence over his own daughters, since she was going to marry his son in the future. Later, in April 1558, she married Henryââ¬â¢s son, the Dauphin Francis, when she was 15 years old. Soon after, in July 1559, when King Henry died, Francis became King Francis II of France, thus making Mary the Queen of France also (Haws Early Life par 1-2). Since Fran... ...he gave birth to her only son James VI. After Henry died, she married the Earl of Bothwell, even after he was accused for the death of Henry (ââ¬Å"Mary, Queen of Scotsâ⬠par 6-12). They ran away together and formed an army to protect them and fight with them (ââ¬Å"Mary Stuart, Queen of Scotsâ⬠par 7-8). Mary had confusing and specified accomplishments in her life, many of which were marriage and her being a queen of many countries. To conclude, Mary had a very hard and complicated life, especially with England tying to kill her. James VI replaced his motherââ¬â¢s throne, and later he took the English throne after the death of Queen Elizabeth I in 1603. Mary was bought up in France. She only had reign over Scotland for 6 years. Mary and Elizabeth I never actually met. Mary died on February 8, 1587 (ââ¬Å"Fun Trivia MQoSâ⬠). ââ¬Å"In my end is my beginning.â⬠ââ¬â Mary Stuart, Queen of Scots.
Friday, July 19, 2019
Indentity Loss Essay -- essays research papers
In The Odyssey and The English Patient the main character, Odysseus and Almasy, suffer from a form of identity loss and try to regain it. They both regain their identity through the help of other people. Every person that stumbles across a piece of their past helps them regain a piece of their identity. Because he cannot remember Almasy must get help remembering his past from the people around him. One of his first memories came from the book ââ¬Å"he brought with him through the fire- a copy of the Histories by Herodotusâ⬠(Ondaatje pg 16). Hana reads some of the notes that he had written in the book; she reads of the different winds ââ¬Å"the ---, the secret wind of the desert, whose name was erased by a king after his son died within it. And the nafhatââ¬âa blast out of Arabiaâ⬠(Ondaatje pg16-17). Before Hana had read this passage Almasy couldnââ¬â¢t tell her the name of the tribe that had helped him after his plane crashed. ââ¬Å"The Bedouin were keeping me alive for a reasonâ⬠(Ondaatje pg 18); Almasy was able to recall what had happened to him and who had helped him. Hana had stumbled on a passage that helped Almasy remember what had happened. Odysseus comes across a piece of his identity in a different way. He goes to the island of Kalypso and she promises him that she will make him a god. The challenge that she put on Odysseus was to go to the island of the dead. Once he was at the island of the dead Odysseus realized that he did was not dead and he wasnââ¬â¢t a god, this meant he was somewhere ...
Thursday, July 18, 2019
The Life of Billy Joel :: Musicians Singers Biographies Essays
The Life of Billy Joel Billy Joel was born on May 9, 1949 in Bronx, New York. He moved at the age of four to a small town on Long Island. This is where at the ripe age of four he discovered the art of music. Originally a classical music fan, Billy Joel honed his skills with classical piano training. This undoubtedly has had a major influence on his life and certainly his music. Growing up Joel was a big fan of such greats as Ray Charles, The Beatles, The Rolling Stones, and Otis Reading. He was greatly persuaded into a career of music when he saw the Beatles perform on the Ed Sullivan Show. Amusingly Joel's first band was inspired by the uncanny opportunity to meet girls. The band was called The Echoes, but this was not the best of times for Joel because his parents were involved in a messy divorce, which included serious financial shortcomings. Joel even began working professional music gigs at night to help support his mother. Joel's schoolwork suffered a little and he began missing school way too often. He was subsequently not allowed to graduate with his high school class due to the number of absences. After high school Joel immediately joined a very popular band called The Hassels for which he recorded two albums with. Within two years Joel was on to a new band which he named Attila, and featured heavy metal drummer Jon Small who he played with during his time with The Hassels. Despite the previous release of two albums Joel still needed to bring in more money so he worked many music related jobs and gigs. He even wrote a rock and roll criticism piece in a weekly column for a magazine. By 1972 Billy Joel was finally on to the big stage when he released his first solo album named, Cold Spring Harbor. He named the album after a small village near his hometown on Long Island's North Shore. This album began to get air time when a Philadelphia based radio station, 93.3 WMMR began playing a live version of a new song called, Captain Jack. Despite its popularity on the east coast, Joel went west in search of some notoriety. He performed in piano bars regularly under the name Billy Martin. This experience is the basis for his hit song, Piano Man. As the popularity of Captain Jack spread west Joel was offered a contract with Columbia Records where he quickly produced top 20 hit, Piano Man.
Merchant of Venice
Alessandro Larosa How does Shakespeare present his ideas (themes, main points, the time, morality and reflection) within the merchant of Venice? Introduction ââ¬â The play, the merchant of Venice, was written by Shakespeare. The play puts forward ideas and themes which are universal and relevant in todayââ¬â¢s life. He uses techniques, dramatic techniques and context to showcase these ideas which form the plot, climax and conclusion of this remarkable play. Body ââ¬â Justice Point: In Venice, 1596, the economic stability was dependant on foreign businessmen like shylock.The city has laws to protect their legal rights and it is how the two religions follow and obey these laws which separate them. Elaboration: In the context of Merchant of Venice, Jews believe in justice, and following the law and Christians are shown to have mercy. Shylock with his bond prepares to cut Antonio's heart, meanwhile the Christian court begs him and asks why he will not show mercy. Shylock repli es saying he doesnââ¬â¢t have a logical reason for why he hates Antonio but he insists on having his bond to for fill his revenge. Example: Shylock has a speech about the courts question. Quote: Tis mine and I will have it. If you deny me, fie upon your lawââ¬â There is no force in the decrees of Venice. I stand for judgment. Answer, shall I have it? â⬠Technique: Metaphor of the pound of flesh used: A pound of flesh is used as a metaphor for justice. Shylock has had his daughter taken away from him like a part of his flesh and he is simply getting it back, while filling his revenge he is also achieving justice within himself. Link: Shakespeare uses justice to make the play realistic; everything in life is controlled by laws. It is the scales of justice which separates the two religions. Wealth over love Point:In Shakespeare's plays he always has involved love. But what could be valued more than love, money. Shakespeare brings forward Wealth over love theme to the play t o create a sense that is the play about lovers and people having a happily ever after or about their personal wealth. Explanation: In the play Christians are noticed as being generous and selfless about their bank account whereas the Jewish people are portrayed as people who are uptight about their wealth and very protective of anything valuable to them. Quotes: Shylock has his daughter taken from him, as he sees it. She actually leaves to marry Lorenzo.When he looks around to find that she has left for Belmont with all of his wealth, he screams. ââ¬ËMy daughter! O my ducats! O my daughter! Fled with a Christian! O my Christian ducats! Justice! the law! my ducats, and my daughter! Link: Shakespeare uses this quote to confuse us. Is Shylock more worried about losing his wealth or of his daughter? Through this quote, Shakespeare also has us thinking another situation. Is this any different from the way Bassonio goes after Portia for her money. In both cases Shakespeare shows that h uman relationships are hard to tell apart from wealth. Appearance vs. reality Point:Another theme that is put forward by Shakespeare in the play is appearance vs. reality. This theme is symbolic of the most universal human problem in the context in The Merchant of Venice and in modern society. Explanation Shakespeare expresses this theme through a dead father of a living daughter Portia. There are three caskets, one gold, one silver and one bronze. The three of them are a game of chance, a gamble laid out in order to find the right suitor for Portia and her fatherââ¬â¢s wealth. One of the three contains a skull, a fools head and the last Portia's picture. Example. The outside of the gold casket promises, Who chooseth me shall gain what many men desire. â⬠Itââ¬â¢s sounds good but it is a trick. Once opened it contains a skull with a smug message, ââ¬Å"All that glisters is not gold. â⬠The Gold casket and skull symbolise that appearances are often deceiving and huma n desire, such as wealth, can be dangerous. The inscription silver casket explains, ââ¬Å"Who chooseth me shall get as much as he deserves. â⬠The inside contains a smiling face of an idiot and with a note that reads, ââ¬Å"So be gone: you are sped. â⬠Whoever chooses the silver casket is a fool who'll get what he deserves (a picture of another fool). Finally, the lead chest.The metal is used to symbolize inner beauty and modesty and contains a picture of Portia. The inscription is very significant, ââ¬Å"Who chooseth me must give and hazard all he hathâ⬠The inscription is symbolic of marriage and reminds us of the fact that Bassanio's battle for Portia literally involves a man who must ââ¬Å"hazard all he hath,â⬠in marriage. Also in relation to Antonio, who risks his life to loan his best friend the money to woo his wife to be. Technique Shakespeare uses juxtaposition with the gold and lead caskets to create a visual representation of Appearance vs. Realit y. The lead casket is gold in disguise. LinkShakespeare expresses the theme through the characters and techniques in the merchant of Venice. The theme is used to engage the audience as we are eager to look behind disguises and find the reality of the characters and the events. Conclusion ââ¬â There are many different themes in The Merchant of Venice which are moral values. To show mercy, to think twice about a book with a glistening cover and to treasure human relationships over the insignificance of wealth. Through the techniques and examples revealed in the Merchant of Venice Shakespeare displays ideas which are extremely significant from when it was first written to present. Merchant of Venice Alessandro Larosa How does Shakespeare present his ideas (themes, main points, the time, morality and reflection) within the merchant of Venice? Introduction ââ¬â The play, the merchant of Venice, was written by Shakespeare. The play puts forward ideas and themes which are universal and relevant in todayââ¬â¢s life. He uses techniques, dramatic techniques and context to showcase these ideas which form the plot, climax and conclusion of this remarkable play. Body ââ¬â Justice Point: In Venice, 1596, the economic stability was dependant on foreign businessmen like shylock.The city has laws to protect their legal rights and it is how the two religions follow and obey these laws which separate them. Elaboration: In the context of Merchant of Venice, Jews believe in justice, and following the law and Christians are shown to have mercy. Shylock with his bond prepares to cut Antonio's heart, meanwhile the Christian court begs him and asks why he will not show mercy. Shylock repli es saying he doesnââ¬â¢t have a logical reason for why he hates Antonio but he insists on having his bond to for fill his revenge. Example: Shylock has a speech about the courts question. Quote: Tis mine and I will have it. If you deny me, fie upon your lawââ¬â There is no force in the decrees of Venice. I stand for judgment. Answer, shall I have it? â⬠Technique: Metaphor of the pound of flesh used: A pound of flesh is used as a metaphor for justice. Shylock has had his daughter taken away from him like a part of his flesh and he is simply getting it back, while filling his revenge he is also achieving justice within himself. Link: Shakespeare uses justice to make the play realistic; everything in life is controlled by laws. It is the scales of justice which separates the two religions. Wealth over love Point:In Shakespeare's plays he always has involved love. But what could be valued more than love, money. Shakespeare brings forward Wealth over love theme to the play t o create a sense that is the play about lovers and people having a happily ever after or about their personal wealth. Explanation: In the play Christians are noticed as being generous and selfless about their bank account whereas the Jewish people are portrayed as people who are uptight about their wealth and very protective of anything valuable to them. Quotes: Shylock has his daughter taken from him, as he sees it. She actually leaves to marry Lorenzo.When he looks around to find that she has left for Belmont with all of his wealth, he screams. ââ¬ËMy daughter! O my ducats! O my daughter! Fled with a Christian! O my Christian ducats! Justice! the law! my ducats, and my daughter! Link: Shakespeare uses this quote to confuse us. Is Shylock more worried about losing his wealth or of his daughter? Through this quote, Shakespeare also has us thinking another situation. Is this any different from the way Bassonio goes after Portia for her money. In both cases Shakespeare shows that h uman relationships are hard to tell apart from wealth. Appearance vs. reality Point:Another theme that is put forward by Shakespeare in the play is appearance vs. reality. This theme is symbolic of the most universal human problem in the context in The Merchant of Venice and in modern society. Explanation Shakespeare expresses this theme through a dead father of a living daughter Portia. There are three caskets, one gold, one silver and one bronze. The three of them are a game of chance, a gamble laid out in order to find the right suitor for Portia and her fatherââ¬â¢s wealth. One of the three contains a skull, a fools head and the last Portia's picture. Example. The outside of the gold casket promises, Who chooseth me shall gain what many men desire. â⬠Itââ¬â¢s sounds good but it is a trick. Once opened it contains a skull with a smug message, ââ¬Å"All that glisters is not gold. â⬠The Gold casket and skull symbolise that appearances are often deceiving and huma n desire, such as wealth, can be dangerous. The inscription silver casket explains, ââ¬Å"Who chooseth me shall get as much as he deserves. â⬠The inside contains a smiling face of an idiot and with a note that reads, ââ¬Å"So be gone: you are sped. â⬠Whoever chooses the silver casket is a fool who'll get what he deserves (a picture of another fool). Finally, the lead chest.The metal is used to symbolize inner beauty and modesty and contains a picture of Portia. The inscription is very significant, ââ¬Å"Who chooseth me must give and hazard all he hathâ⬠The inscription is symbolic of marriage and reminds us of the fact that Bassanio's battle for Portia literally involves a man who must ââ¬Å"hazard all he hath,â⬠in marriage. Also in relation to Antonio, who risks his life to loan his best friend the money to woo his wife to be. Technique Shakespeare uses juxtaposition with the gold and lead caskets to create a visual representation of Appearance vs. Realit y. The lead casket is gold in disguise. LinkShakespeare expresses the theme through the characters and techniques in the merchant of Venice. The theme is used to engage the audience as we are eager to look behind disguises and find the reality of the characters and the events. Conclusion ââ¬â There are many different themes in The Merchant of Venice which are moral values. To show mercy, to think twice about a book with a glistening cover and to treasure human relationships over the insignificance of wealth. Through the techniques and examples revealed in the Merchant of Venice Shakespeare displays ideas which are extremely significant from when it was first written to present.
Wednesday, July 17, 2019
Provide Leadership Across the Organisation
PROVIDE drawSHIP cross rooms THE ORGANISATION ASSESSMENT BY CHARLOTTE MCMANUS LEADER The 14th Dalai genus genus genus genus genus genus genus genus genus genus genus Lama 1. INTRODUCTION The tenableness for selecting the Dalai Lama is because he has wind many things in his life and is now considered amongst many researchers and writers, as one of the greatest bequeathership of inherently time. He has been a attracter of a country, a religion, and more than signifi piece of asstly, the leader of the phantasmal knowledge domain. He is a fascinating quality that has experient many difficult situations which increases the intrigue of this leader and the skills that he possess.He leads and promotes a way of life that encapsulates e precise kind-hearteds, in entirely countries, of all religions, and uses genuinely anomalous lead skills, which countenance behind be very(prenominal) kindle to study. 1. 2BACKGROUND The Dalai Lama is a re-incarnation of a big line (13 before him) of tulkus(an beginner Tibetan Buddhistic lama/t separatelyer) who settle from thebodhisattvaAvalokitesvara. The first Dalai Lama was Gendun Drup who lived in 1391 1474. Tenzin Gyatso was enthroned as the 14th Dalai Lama in 1940 when he was five years old, and assumed impermanent responsibility of Tibet (www. alailamafoundation. org) when he was 15 years old. He experienced an invasion of Tibet by the Chinese and escaped into transport in India when he was 24, making him the first of all time Dalai Lama ever to leave Tibet. The Dalai Lama has dedicated his life to promoting a innovation free of violence and suffering, where all reputation can live in pink of my John and harmony together, irrespective of nationality and religious beliefs. He relys that by means of conjecture, compassion and the respect for all life, each person will get to happiness and contentment in their life. 1. 3ACHIEVEMENTSThe Dalai Lama has come acrossd many things in his life to da te, including cosmos awarded with one of the most recognised awards in the reality in 1989 The Nobel Peace Prize, which is a true indication of his world-recognised contri saveions to promote peace. To achieve this award the Dalai Lama has spent his entire life striving to create a more peaceful environment for the tender-hearted race, with a great focus on reclaiming human rights in Tibet. This mission has seen him journey all oer the world, tincting with leaders of many countries presenting new initiatives and being stern in his message and strength to get back these issues.These include his appeals to the United Nations during his exile, in 1959, 1961 and 1965, which resulted in one-third resolutions being adopted by the General Assembly. In 1987 he presented the flipper Point Peace Plan to the congressional Humans Rights Caucus. This was an appeal to the US relation for the restoration of human rights in Tibet and to say it as a zone of peace, thusly stopping the dumpi ng of nuclear profusion in Tibet, as well as urging earnest negotiations on the upcoming of Tibet and relations between the Tibetan and Chinese people (http//nobelprize. org).In 1989 he offered the substance Way Proposal at the European Parliament, which was not accepted, however, the Dalai Lama again proposed this in 1996 and 1997, when a preliminary opinion analyse was held and the policy was adopted by Parliament. In April 1991, Tenzin Gyatsu travelled to the US and met with George Bush, which ended a boycott with the nation, and as well as resulted in US Congress passing the Tibetan polity Act 2002, formalising US fill-in for parley between China and the Dalai Lama, and besides providing funding to Tibet for development projects within the country. This was a very strategical decision ade by the Dalai to create a valuable race with one of the most authorful counties in the world, and in addition resulted in the US apportion the Dalai Lama with the highest civilian award, the Congressional halcyon Medal, in 2007. Whilst negotiating with parliaments and congress worldwide, the Dalai Lama has rebuilt communities for those spirit in exile, set up educational, ethnical and religious institutions all everywhere the world to assist in maintaining the Tibetan glossiness and apprise Buddhism. He still continues to lead a population of an estimated 500 billion Buddhists worldwide (http//www. thedhamma. com). 1. 4LEADERSHIP CHARACTERISTICSIt is very clear that the Dalai Lamas objectives be to restore equality, respect, organized religion and mutual benefit (www. nobelprize. org) between Tibet and China. His concerns ar for all members of the human family (www. nobelprize. org), and he has stay puted lucid and relentless in his message which has resulted in loyalty and dedication from his pursuit. Personal value are very important to this leader, and he sets a lesson example to his following, stock-still also during the most difficult sit uations he still appears to act rationally. For example, it is inform that 20% of the Tibetan population deem died in combat with the Chinese (www. dityabirla. com), yet he systematically acts with integrity, compassion and empathy, whilst remaining strategic and controlled in his negotiations with this nation. The Dalai Lamas value and morals are what lead him this encourages his followers to also align their values with his. He sticks to his principles of right conduct, and thusly sets a moral example to his followers, which results in their unwavering assert for him and his cause. These values and morals have prevented the Dalai Lama from behaving violently when in a menacing situation as they are authority of his psychological makeup, and moral reasoning.Theory Y is applicable in this scenario as the Dalai Lama leads on the premise that people are intrinsically motivated, meaning that how they feel will impact and influence them more than outside motivation. Because of hi s spiritual strengths the Dalai Lama has developed the highest phase of moral reasoning, which as Kohlberg has expressed is not always possible. Whilst Gyatsus morals remain the most important driver in his leadership, his culture is also something he is very proud of and is something that he is consistently working(a) to retain.This is evident with his part in the leading the development of towns of Tibetans in exile across the world that celebrate and sleep together the Tibetan culture, in particular, Buddhism, which has also all the way driven his behaviours and attitudes towards life. There are legion(predicate) conclaves following the Dalai Lamas Buddhist breedings, with followers travelling all over the world to get the opportunity to meet or listen to his teachings live. This group cohesiveness ensures reciprocal influence and maximises the influence of his messages, which is other reason why the Dalai Lama spends so much of his time travelling.He on a regular basis visits these groups to minimise interpersonal conflicts between the groups. It also allows for new groups to form at each event, which results in the group development work repeating itself by dint ofout the world. The Dalai Lamas leadership is both authentic and servant leadership. He promotes self-awareness, openness and inclusivity within the human family, yet he also acts as a servant for the people of Tibet to clamber for their right to live in peace. I would say that the Dalai Lama is a transformational leader who provides heap for his followers and inspires them to embrace his vision of peace and happiness for all.He allows them to trance of what they can achieve, then designs a way for them to achieve it, and then continues to develop it through initiatives and programs that allow the vision to materialise, as we have seen in section 1. 3 Achievements. 1. 5TYPE OF personnel Due to his come out within the Buddhism companionship the Dalai Lama possesses referent powe r over his followers, this has developed over a long period of time, which has allowed his followers to witness his leadership skills and what he is prepared to experience/ grant for his beliefs.This has resulted in his following growing consistently over the past 70 years, as people give, respect and love him, and then increasing his influence and support. As it is believed that the Dalai Lama is a reincarnation of the 13th Dalai Lama he also possesses a aim of legitimate power that has been passed down to him when he was enthroned as the 14th Dalai Lama. This legitimate power would only be relevant to those that believe in Buddhism, therefore believe in the concept of reincarnation.This legitimate power is not a power that the Dalai Lama exercises, as he claims that he is a unsophisticated monk from Tibet, I am no one special (Nobel Prize espousal speech). This claim also contributes to the respect that his followers have for him and also helps them relate to him through his personalised leadership, resulting in stronger bonds being formed. The Dalai Lama is also a community leader, as he does not have position power from any country, and also has minimum resources to glide by his message through.He also possesses the skills to build social capital, as discussed above and mobilisation, through the travel he does all over the world to communicate with his followers. 1. 6PERSONAL TRAITS The Dalai Lama uses his personal traits to communicate with people more effectively, which in turn ensures he gains their trustingness and respect. He is often smiling at people, listens intently, and always maintains eye contact with the audition or speaker. He appears to be promiscuous discussing all topics and never interrupts the speaker during conversation, but listens, encourages them to continue and then responds calmly.The Dalai Lama speaks three wordss, Tibetan, Chinese and side of meat. This ensures he can communicate and connect strongly with his fellow c ountrymen in Tibet. It is also important that he can communicate effectively with those that he has conflicts with, the Chinese. English is also a language he has learnt, as this is the most common language spoken in the Western world and therefore means maximum picture show of his message to those across the world.When people intercourse most their encounter with the Dalai Lama, many call forth his insatiable laugh and kind smile that result in them warming to him (www. youtube. com) and today wanting to listen and absorb his message. It has been reported by some, that he possesses an aura that has an surprisingly positive effect on a person and is communicated to the receiver purely through facial expressions, including eye contact. As these purviews of the converse process makes up 50% of the message, it therefore ensures clarity and understanding for the receiver of the message. . 7LESSONS TO BE LEARNT The Dalai Lama has a lot to teach those that analyse his leadership sk ills, but I would say that the most profound teaching is that you essential connect with your followers, by gaining their trust and commitment. This can only be achieved by being consistent in your message, whilst playacting with integrity, and providing your group or team with a vision, and assisting with achieving the final goal through support and development of the vision.It is also important to leave regrets behind and take out front the lessons which have been learnt by past mistakes, which ensures group cohesion, therefore maximising the chances of achieving that goal or objective. To be a made leder you must be passionate about achieving your objective, as this will be communicated to your followers, therefore promote loyalty and passion iin them, whilst inspiring them to achieve their goal. Mentoring is also another important aspect of leadership, as it ssists in the changing of behaviours and also encourages aspirations in the less experienced, whilst passing on valua ble skills and lessons learnt from a more experienced leader. This has been apparent by the lessons and support that the Dalai Lama has received from many leaders somewhat the world, including religious political and organisational, and also by the time he spent as a child learning about Buddhism and Tibetan culture. 1. 8CONCLUSIONIn conclusion, it has been very interesting and inspiring to read about this leader, i have learnt about many skills that are required to be a successful and inspirational leader. However, this spiritual leader whitethorn have many more skills that I believe cannot be duplicated without many hours of meditation and the study of his culture. Yet, this in itself highlights how effective the Dalai Lama is in communicating his message in relation to Buddhism, and how inspirational he sincerely is.
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